Molecular Field Software

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Cresset's unique Field technology provides an unique insight into the way molecules are seen by proteins. Field Point descriptions of molecules have been used widely to provide richer, more informative views of the way in which ligands interact with proteins, to inter-relate compounds from different chemical series that act at the same protein site (FieldTemplater), to find novel chemical series through virtual screening (FieldScreen), and to decode Structure Activity Relationships (SAR) by comparing molecules as proteins 'see' them (FieldAlign). Field Point technology has now been used to provide a much more accurate basis on which to identify novel, chemically relevant bioisosteres (FieldStere).

Cresset's products include:

FieldStere™: Discover non obvious drug candidates through bioisosteres. This easy to use but powerful technology gives you rapid access to new backup series, improved library designs, faster lead optimisation and improved patent definitions. Take a quick tour
FieldScreen™: Find new active chemotypes through highly effective, ligand-based virtual screening. Unlike other methods, FieldScreen gives you lead like hits that can rapidly developed into leads.
FieldTemplater™: Gain understanding of how your molecules relate to each other and how they bind to the target protein. Simply input your molecules in 2D and FieldTemplater will produce a detailed model of binding. It is ideal for GPCRs and ion channels, or any target lacking x-ray data. Take a quick tour
FieldAlign™: Gain new insights into your molecules and their activity with this easy to use design and SAR tool for chemists - align any molecule drawn in 2D to a 3D molecular field template. Take a tour of the GUI or see how to easily create alignments