Hit finding

Cresset can find you multiple starting points for your medicinal chemistry programs

Starting from an active ligand, we search through more than 2.5 million commercially-available compounds to find multiple, structurally diverse hits for you. The search ligand can be a natural or synthetic peptide, a competitor's drug, or an HTS hit with poor ADMET properties for example. The only information which we require is the likely active conformation of a single known ligand. If the conformation is not known, Cresset's modellers can use FieldTemplater™ to determine it from analysis of as little as three structurally diverse actives, either proprietary or from the literature.

The known ligand need not be drug-like. Cresset's field technology allows us to make the leap from peptides to non-peptides, steroids to non-steroids or from structures with significant ADMET or IP liabilities to new scaffolds free from patent issues. As all the hits are real compounds, SAR follow-up and synthesis of analogues is straight forward, accelerating your hit to lead process.

Cresset provides hit-finding searches with FieldScreen™ on a fee-for-service basis: all of the IPR in the compounds that we find belongs to you. Projects normally take two to four weeks.

We have worked on a wide variety of targets including:

Class A GPCRs	Class B GPCRs	Chemokines
Opioid receptors	Steroid receptors	Ion channels
Kinases	Proteases	Matrix metalloproteases
Enzymes	Antibodies	Beta-amyloid aggregation

A partial list of the successes we have had at finding new lead series for our clients is in the case study section. We average an 80% success rate, and have done more than 30 projects in the last four years. Whatever the nature of your project, we can help you succeed faster.