FieldStere
generate non-obvious drug candidates
For a free evaluation simply talk to George
+44 1707 356 120
FieldStere to become even more versatile
A new release of FieldStere is due soon with many new features that will
- increase accuracy of results
- increase information content
- Reduce time to evaluate results
You will love the new "Results Tree" that enables you to cluster the bioisosteres together. Also FieldStere 1.1 comes with the ability to filter your results so it will be easier than ever to find exactly the bioisostere that you need.
FieldStere 1.1 will incorporate many of the new features in the latest releases of FieldAlign and FieldTemplater including visualising Fields as surfaces and using protein excluded volumes.
See the power and ease of use of FieldStere for yourself with an interactive tour.
FieldStere™ is a powerful new tool for medicinal chemists that provides an innovative way to find molecules that share a common activity but which are structurally unrelated.
FieldStere gives you
- Idea generation
- Greater diversity of synthetic targets
- Rapid access to potential back up or follow series
- Improved designs
- Shorter Lead Optimisation
- Rapid assessment of IP coverage
- Safer patents
FieldStere's simple but powerful interface has been designed for
- Medicinal Chemists
- Research Managers
- Synthetic Chemists
- Computational Chemists
- Patent Agents
Alternatively, let Cresset's experienced scientists help you directly. We offer services that will kick start your drug discovery project.
FieldStere has broad applicability, reducing the time and costs involved in all stages of the drug discovery process:
- hit identification
- hit to lead
- lead optimisation
- patent protection
- patent challenging
- portfolio management and assessment
FieldStere works by finding pre-existing fragments that are isoelectronic and isosteric for the part of your molecule that you wish to replace. Uniquely, FieldStere uses these potential bioisosteres to create a product molecule which is scored against your initial target using Cresset's proprietary Field technology. This approach results in
- Greater accuracy, fragment properties influence the retained portions of the target molecule and vice-versa
- Increased range of results:
- Obvious bioisosteres building trust in the approach
- Less obvious bioisosteres increasing diversity
- Non obvious bioisosteres expanding your research horizons
- Valuable become physical properties part and parcel of the results
- Medicinal chemistry friendly output allowing synthetic targets to be viewed easily
The range and quality of the results from FieldStere increase the medicinal chemist's repertoire and present novel product opportunities that are unprotected by existing patents. As a result, FieldStere has application in the development of patent strategy for the protection of new molecular entities, identifying follow-on compounds as marketed products come off patent.
FieldStere will redefine you intelectual property landscape. Interested? Talk to George about a free evaluation. See FieldStere in action with one of our webclips
Example: Using FieldStere with Vioxx as a starting structure, the non-obvious 12nM COX-2 inhibitor from Merck (2D sim 0.5) was retrieved at position 27 (searched 205,000 fragments). Other known COX-2 inhibitors occurred at positions: 3 (Valdecoxib), 7, 8, 9 and 18
+44(0)1707 356120