FieldScreen

proven technology to find new chemotypes

For a free evaluation simply talk to George
+44 1707 356 120

Using the information contained in known actives, FieldScreen™ finds new hits and leads from large databases. It has been employed within Cresset on 60+ projects with a success rate of 80% and is in daily use within several large pharmaceutical companies. Using FieldScreen you:

Increase diversity of hits and leads
Gain starting points for difficult targets
Improve lead-like properties of hits
Discover new back up series
Reduce screening costs
Rescue HTS false negatives

FieldScreen can be accessed by

Computational Chemists
Medicinal Chemists

Alternatively you could access FieldScreen using Cresset's highly cost effective services.

Unlike other virtual screening methods, FieldScreen requires very little information up front. We have had successful projects using as little as a single active compound as the input.

FieldScreen preferentially returns "lead-like" hits. In tests on the "DUD" dataset, FieldScreen preferentially retrieved molecules in the 350-370 MW range, significantly lower than other methods. This analytical test nicely mirrors Cresset's experience where we have consistently found lead like hits for our clients.

FieldScreen consistently out performs other methods when considering chemotype enrichment. This means a greater diversity of hits are delivered to your project.

FieldScreen is remarkably easy to use. Simply:

Log on to the server using a web browser
Upload a single (or multiple) active in the best conformation
Follow the wizard through file conversion and database selection
Choose how many molecules to refine with low or high accuracy
Download the results in text, sdf or mol2 format
View the results as 2D structures and the resulting 3D alignments side by side in our own viewer

Studies on real client data have demonstrated its ability to find completely novel hits from screening just a few hundred compounds rather than hundreds of thousands. Successful collaborations have replaced peptide with non-peptide and steroid with non-steroid leads, as well as finding novel leads starting from known drug-like molecules.

FieldScreen's easy to use web interface is great for most tasks. However, it can be readily customized by expert users to run and analyse searches automatically via the Linux command line.

FieldScreen will re-invigorate your drug discovery program. Talk to George about a free evaluation or let Cresset take the strain, our project services are a cost effective solution for finding new leads.